This article identifies the major enablers and inhibitors in the achievement of business-Information Technology (IT) alignment. Alignment involves the activities that management performs to achieve cohesive goals across the IT and functional (e.g., finance, marketing, manufacturing) organizations. Therefore, alignment addresses both how IT is in harmony with the business, and how the business should or could be in harmony with IT. IT requires strong support from senior management, good working relationships, strong leadership, appropriate prioritization, trust, and effective communication, as well as a thorough understanding of the business environment. This article develops a methodology that leverages the most important enablers and inhibitors to business-IT alignment.